Host-pathogen interaction of PRRSV- 1 with target immune cells and in pigs

The main objective of the project is to study the host-pathogen interaction of PRRSV-1 with target immune cells and in pigs. The hypothesis is that PRRSV-1 can be resolved by the host without the use of neutralising antibodies. The approaches to study the host-pathogen interaction of PRRSV-1 in vitro and in vivo shall include the: 1) Use of in vitro systems to demonstrate effect of infection on APC 2) Analysis of innate immune mechanisms that precede the appearance of the adaptive immune response • The studies will determine the events in the tonsil and retropharyngeal lymph nodes • Thereby determining the change in the innate and adaptive cellular composition