Ultra-stable Optical Tweezers Microscope

Technologies for the manipulation and sensing of individual molecules has been developed in recent years, which allow for the quantification of conformational transitions, forces, and energies. This manipulation ability can now be combined with single-molecule fluorescence detection, which enables direct detection of bound molecular species. The aim of the investment is to meet the demands for these state-of-the-art single-molecule studies, at the highest force resolution and stability in time, light sensitivity, and novel microfluidic flow capabilities. For this purpose, a new optical tweezers instrument will be purchased, which will be installed in the laboratory at AMOLF. 1 ultra-stable Optical Tweezers Microscope